Maarten Sonnaert was awarded "Best Oral Presentation, 3rd place" by the student and young investigator section of Termis for his presentation entitled "3D perfusion bioreactor culture of human periosteum derived stem cells for bone tissue engineering" at the 2013 Termis European chapter meeting in Istanbul, Turkey.

Prometheus proposes the second Belgian Symposium on Tissue engineering," micro to MACRO: translating between scales "

Nick van Gastel received a Young Investigator Award from the American Society for Bone and Mineral Research (ASBMR) for his oral presentation “Interactions between Periosteal Cells and Muscle-Derived Blood Vessels are Essential for Bone Autograft Healing“ at the 2012 Annual Meeting of the ASBMR in Minneapolis, Minnesota, USA.

Greet Kerckhofs was awarded "Best Oral Presentation" for her presentation entitled "High-resolution non-destructive 3D quantitative imaging of the cartilage subarchitecture" at BSTE 2012, Leuven, Belgium
The article entitled "A Semi-Autonomous Model of Endochondral Ossification for Developmental Tissue Engineering "  by H.E. Weiss and S.J. Roberts et. al. has been featured on the cover page of Tissue Engineering Part A, Volume 18, Issue 13-14, July 2012.



Prometheus, the division of Skeletal Tissue Engineering of the K.U.Leuven, is an interdisciplinary initiative focusing on skeletal tissue engineering (TE) research and technology transfer, founded by the Divisions of Rheumatology, Orthopaedics, Biomechanics, Experimental Medicine and Endocrinology and Prosthetic Dentistry, and the Department of Metallurgy and Materials Engineering. The Prometheus platform runs 3 integrated programs:

(i) fundamental science related to stem cells and 3D tissue creation.
(ii) translation of scientific findings into a technological plan for manufacturing processes, quality and safety.
(iii) creation of blue prints for the clinical implementation of a bone TE therapy.

These 3 programs are divided into 6 research tracks that are coordinated by experts in the field and are supported by a broad technology platform and state-of-the-art infrastructure that is based on:

(i) adult stem cell protocols & gene therapy.
(ii) multiscale computational modelling from molecular, over cell and tissue, to patient level.
(iii) scaffold design, manufacturing and characterisation.
(iv) instrumented bioreactors.
(v) clinically relevant in vivo models.
(vi) a knowledge & technology network linked to clinical practice.

At present the Prometheus interdisciplinary research team consists of about 40 people, ranging from technicians, over PhDs, post-docs to orthopaedic surgeons and a management. The founding Prometheus scientists have discovered pathways that have been identified as critical in the formation of skeletal tissues, made contributions to the characterisation of stem/progenitor cells and to the clinical development and technology transfer of cell based therapies for skeletal repair, have extensive experience in clinical evaluation of new therapies and are experienced in project management of national and international projects related to bone tissue engineering and biomaterials. Part of these scientific achievements has been transferred into the spin-off TiGenix NV. The scientific success of this research group is indicated by the fact that the Prometheus scientists generated 70 unique peer-reviewed publications relevant to skeletal TE in the last three years in high quality journals. This is reflected by an h-index on Thompson ISI of 50. Prometheus had 29 grants on skeletal regeneration ongoing in the last three years for a total of €5,43 million.


Dr. ir. Jan Schrooten

Division of Skeletal Tissue Engineering
KU Leuven
O&N 1
Herestraat 49 – bus 813
3000 Leuven

Tel 1: +32 16 32 12 12
Tel 2: +32 16 34 61 89

Fax 1: +32 16 32 19 92
Fax 2: +32 16 34 62 00